Can broccoli help in Osteoarthritis
In the June 2017 edition of Nature’s Scientific reports,
researchers in the United Kingdom reported on their continuing studies on the
effects of broccoli on osteoarthritis.
The research team lead by the School of Biological Sciences,
University of East Anglia, Norwich and with the University of Liverpool had
previously reported that sulforaphane, a dietary isothiocyanate (a sulfur based
chemical group found in broccoli), derived from its glucosinolate precursor
(glucose,amino acid) can prevent cartilage destruction in cells. These results
were reported in animals and in laboratory experiments.
In the next phase of this research, the researchers enrolled 40
patients with knee osteoarthritis undergoing total knee replacement into a
proof-of-principle trial. (A first phase study that suggests benefits in
humans. Knee replacement patients were chosen because they clearly had degenerative
knee disease.)
Patients were randomly divided
to either a low or high glucosinolate diet (broccoli) for 14 days prior
to surgery.
The researchers found dietary isothiocyanate in the synovial
fluid of the high glucosinolate group, but not the low glucosinolate group.
Here is how the study concluded:
This study clearly demonstrates that a dietary bioactive with
chondroprotective properties can penetrate the knee in osteoarthritis.”
Simply, eating broccoli helped patients with knee osteoarthritis
by protecting the knee cartilage.
There have been many studies on the benefits of sulforaphane
from Broccoli ranging from helping children with autism, diabetes, cancer,
heart disease and other immune disorders. In part, this is due to Broccoli’s
antioxidant effects and its ability to change the cellular environment from
disease to healing.
In an earlier study from 2011, researchers at the University of
Bologna in Italy publishing in the Journal of cellular physiology found that
sulforaphanes could stop cartilage cell death by exerting pro-survival and
anti-apoptotic (anti-death) actions and influence signaling pathways in a
variety of experimental conditions employing chondrocyte cell lines and
osteoarthritic chondrocytes treated with a range of death stimuli.
What does all this mean?
Our body’s immune system is programmed to kill invaders
(bacteria, virus, fungus infections), mutations (cancer and immune disorders)
and damaged tissue as in osteoarthritis. This is one of the reasons our
cartilage breaks down and we go bone-on-bone. The body removes damaged
cartilage faster than we can regrow or repair it.
The Italian research team found that sulforaphanes slowed this
premature kill off of cartilage cells which allowed healing to take place.
Broccoli is yet another food that can help your joints change
from a diseased joint environment to a healing joint environment.
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